Dollar cost comparisons of in vitro and in vivo methods

Toxicity Endpoint Typical Cost Per Assay
Ocular corrosivity/irritation
In vivo test Ocular irritation $1,800
In vitro test Bovine Corneal Opacity and $1,400
Permeability test
Skin corrosivity
In vivo test $1,800
In vitro test:
EpiDerm™ $850
CORROSITEX™ $725
Skin Sensitization
In vivo test: $3,000 – 6,000
In vitro test: LLNA $3,000
Pyrogenicity: In vitro test: $400
In vivo test: Endosafe-IPT $110
Genotoxicity
Chromosomal aberration
In vitro test: $20,000
In vivo test: $30,000
Sister chromatid exchange
In vitro test: $8,000
In vivo test: $22,000
Unscheduled DNA synthesis
In vitro test: $11,000
In vivo test: $32,000

Chart provided courtesy of PETA